Bryant has broken bone in knee - Lakers
Kobe Bryant of the Los Angeles Lakers stands during a free throw against the Atlanta Hawks at Philips Arena on December 16, 2013 in Atlanta
"You hate it for Kobe," Lakers coach Mike D'Antoni said in remarks posted on the team's Twitter feed. "He's worked so hard to get back."
Bryant missed the first 19 games of the season as he continued to recover from surgery to repair a torn left Achilles tendon suffered in April.
He had played just six games and averaged 13.8 points.
Bryant was injured Tuesday in the third quarter of a 96-92 win over Memphis. He walked carefully to the bench but returned later to the contest and finished with 21 points.