Barcelona v AC MIlan
The other glamour tie of this round - together they have 11 European Cups.
Perennial favourites Barcelona, champions in 2009 and 2011, are currently nine points clear in La Liga but received a hammer blow on Wednesday when it was revealed coach Tito Vilanova was facing surgery after cancer returned to his salivary gland.
His assistant, Jordi Roura, has been placed in temporary charge.
"Yesterday (Wednesday) was a very hard day, a tough blow," said Barca captain Carles Puyol in comments posted on the club's official Twitter feed.
"Tito gave us strength, already talked about coming back. Personally, I'm happy about facing Milan. Not because it's an easy opponent but because it's a team I've always liked."
Milan may be 7th in the Serie A currently but never write them off in the Champions League.
The two locked horns four times in last season's competition, with Barca finishing above Massimiliano Allegri's side in the group phase and then prevailing 3-1 on aggregate when they met again in the last eight.