Goals by Bosnia centre-back Emir Spahic and Poland left-back Sebastian Boenisch for Leverkusen cancelled out Marvin Plattenhardt's equaliser in the first-half from a direct free-kick which left the visitors 2-1 up soon after the break.

Leverkusen's South Korea star Son Heung-Min made sure of the victory when he sprinted clear on a counter-attack and drew the defence for Spahic to tap home his second with ten minutes left.

Ex-Germany international Roberto Hilbert grabbed Leverkusen's fourth seven minutes later having come off the bench to complete the rout.

Leverkusen lead Wolfsburg by a single point in the table with just three games left to decide Germany's fourth Champions League place after Wolves had spent 24 hours in fourth after Saturday's 3-1 win at Hamburg.

Leverkusen enjoyed their second straight win since ex-Liverpool captain Sami Hyypia was sacked as coach, while Nuremberg suffered their fourth straight defeat which leaves them second from bottom.

On Saturday, champions Bayern Munich ended a run of three Bundesliga games without victory with an unimpressive 2-0 win at bottom club Eintracht Braunschweig ahead of Wednesday's Champions League semi-final, first-leg at Real Madrid.

Peru veteran Claudio Pizarro, 35, and Croatian striker Mario Mandzukic were on target with late goals in what was only Bayern's third win in their last seven games in all competitions.

Bayern were without Manchester United-target Toni Kroos and Rafinha, who were both suspended, while left-back David Alaba was missing with a cold.

Germany goalkeeper Manuel Neuer sat out the trip to Braunschweig as he recovers from a calf injury with reserve shot-stopper Lukas Raeder stepping in for the third time.

- historic first relegation -

The victory leaves Bayern on 81 points and 17 points clear of second-placed Dortmund who picked up their fifth straight win.

Borussia enjoyed a 4-2 victory at home to ten-man Mainz 05 as coach Jurgen Klopp faced his former side having coached them from 2001-08.

Dortmund took the lead after just six minutes through a curious goal when Milos Jojic's strike went in off the upper arm of Borussia's Oliver Kirch, but despite furious protests the goal stood.

Japan striker Shinji Okazaki scored twice for Mainz to make it 2-2, his second after pouncing on a terrible back pass from Dortmund's Nuri Sahin. The Japanese international scoring either side of Bayern-bound Robert Lewandowski's strike for Dortmund.

Dortmund made sure of the three points, which confirmed their Champions League direct qualification, with goals by defender Lukasz Piszczek and Germany winger Marco Reus, who converted a penalty 12 minutes from time after Mainz had centre-back Niko Bungert sent off for a handball.

Ten-man VfL Wolfsburg romped to a 3-1 win at Hamburg as goals by Ivan Perisic, Kevin de Bruyne and Ivica Olic gave Wolves a 3-0 lead just after the break before Hamburg's Ivo Ilicevic scored a consolation for the hosts who remain third from bottom.

Wolves were reduced to ten men when Brazil midfielder Luiz Gustavo was sent off for a second yellow card on 90 minutes.

Hamburg are facing an historic first relegation from Germany's top flight.

Freiburg are virtually assured of their survival as their 4-2 win at home to ten-man Borussia Moenchengladbach left them eight points above the relegation places with three games left.

Likewise, Werder Bremen are set to stay in the Bundesliga as their 3-1 win at home to Hoffenheim lifted them up to 11th and nine points from danger while mid-table Hertha Berlin and Augsburg shared the points in a goalless draw.