The Argentine has become a key part of Carlo Ancelotti's side since the Italian switched to a 4-3-3 formation at the start of 2014 and is likely to be replaced by Asier Illarramendi or Isco.

Brazilian international left-back Marcelo is also missing for Madrid due to a hamstring strain, whilst Dortmund are without six first-team regulars through injury and suspension, including top scorer Robert Lewandowski.