Fulham's 13-year run in the English top flight was ended by a 4-1 defeat at Stoke City, while Cardiff went straight back down to the Championship following a 3-0 loss at Newcastle United.

Both sides' fates were sealed by fourth-bottom Sunderland's unexpected 1-0 win at Manchester United, which took Gus Poyet's side four points above Fulham and five points clear of bottom club Cardiff.

Sunderland can secure their own survival by winning their game in hand at home to West Bromwich Albion on Wednesday, although they will effectively be safe if Norwich City lose at Chelsea on Sunday.

Peter Odemwingie put Stoke ahead in the 39th minute against Fulham at the Britannia Stadium, converting from close range after Stephen Ireland's shot hit the bar.

Marko Arnautovic made it 2-0 nine minutes into the second half, slamming a first-time effort into the roof of the net from Odemwingie's pass.

Further goals from Oussama Assaidi and substitute Jonathan Walters sealed Fulham's fate, with Kieran Richardson replying in vain for the visitors.

"I've never been relegated until today," said Fulham manager Felix Magath. "I feel very sad. I have to apologise for not managing the situation. The club asked me to come. I tried.

"Regarding today, the only thing I can imagine is there was too much pressure for the players. There was no reason for that performance -- it's the worst game since I've been here."

Shola Ameobi, Loic Remy and Steven Taylor scored the goals for Newcastle that condemned Cardiff to an immediate return to the second tier after their promotion from the Championship last year.

Newcastle's win ended a run of six successive defeats and came despite a mass fan walkout in the 69th minute in protest at the club's management.

"The realisation that we're down is one of the most bitter disappointments of both mine and many of the players' careers," said Cardiff manager Ole Gunnar Solskjaer.

- United's seventh home defeat -

Cardiff and Fulham succumbed to relegation despite both changing their managers during the campaign.

Solskjaer succeeded the sacked Malky Mackay in January, while Magath is Fulham's third head coach after Martin Jol and Rene Meulensteen.

Sunderland's success at Old Trafford, in Ryan Giggs's second game as United's interim manager, was their third victory in a row and followed a 2-1 win at Chelsea two weeks ago.

Sebastian Larsson scored the game's only goal on the half hour, steering in from Connor Wickham's pass to condemn United to a 12th league defeat of the campaign; seven of which have come at home.

United last lost seven league games in the 1973-74 campaign, when they were relegated to the old Division Two.

"I feel flat. The players were flat and I don't know why," said Giggs.

"We've had a problem at home all season. It's not been good enough."

United's defeat means that Tottenham Hotspur remain in pole position to secure sixth place, and with it Europa League qualification, despite having lost 2-0 at West Ham United earlier in the day.

Tottenham centre-back Younes Kaboul was sent off in the 25th minute for a last-man foul on Stewart Downing and after a Harry Kane own goal gave West Ham the lead, Downing made it 2-0 with a free-kick.

Spurs continue to lead United by six points, having played a game more.

Elsewhere, Andreas Weimann scored twice as Aston Villa won 3-1 at home to FA Cup finalists Hull City, while Southampton striker Rickie Lambert scored a 93rd-minute winner in a 1-0 victory at Swansea City.

Later on Saturday, Manchester City can take over from Liverpool at the top of the table on goal difference by winning at fifth-place Everton.

Liverpool's 2-0 loss at home to Chelsea last weekend means that City will effectively be assured of winning the title -- barring an improbable goal difference swing -- if they win their last three fixtures.