The world player of the year picked up a knee injury in last Wednesday's 3-0 first-leg win in the Spanish capital and then pulled out of training in Germany on Monday after just 20 minutes.

Coach Carlo Ancelotti instead moved Angel Di Maria into the Madrid attack alongside Gareth Bale and Karim Benzema, while Asier Illarramendi was brought into the midfield in place of Isco.

Dortmund welcomed back Poland striker Robert Lewandowski, who missed the first leg due to suspension, but coach Jurgen Klopp was forced to name a make-shift pairing in central midfield.

With captain Sebastian Kehl suspended and Nuri Sahin, who has been struggling with a back injury, only on the bench, Klopp handed starts to Oliver Kirch and recent signing Milos Jojic.

German internationals Sven Bender and Ilkay Gundogan are also out injured.

Starting line-ups in the Champions League quarter-final, second-leg match between Borussia Dortmund and Real Madrid at the Westfalenstadion on Tuesday:

Borussia Dortmund (4-2-3-1)

Roman Weidenfeller (capt); Lukasz Piszczek, Manuel Friedrich, Mats Hummels, Erik Durm; Oliver Kirch, Milos Jojic; Marco Reus, Henrikh Mkhitaryan, Kevin Grosskreutz; Robert Lewandowski

Coach: Jurgen Klopp (GER)

Real Madrid (4-3-3)

Iker Casillas (capt); Dani Carvajal, Pepe, Sergio Ramos, Fabio Coentrao; Asier Illarramendi, Xabi Alonso, Luka Modric; Angel Di Maria, Gareth Bale, Karim Benzema

Coach: Carlo Ancelotti (ITA)

Referee: Damir Skomina (SLO)