Having earned a 1-1 draw in the Istanbul leg three weeks ago, Schalke face an anxious wait to hear if last season's top-scorer in the Bundesliga will be fit for the match at Gelsenkirchen's Veltins Arena.
Schalke claimed their second Ruhr derby win of the season at home on Saturday, but Huntelaar had to be carried off on 53 minutes after damaging ligaments in his left knee.
The Dutchman, who later posted a picture of himself in the back of an ambulance on Twitter, has scored in his last two games after also netting in last week's 4-1 league win against Wolfsburg.
