Everton marked their first appearance in Europe since the 2009/2010 season with a 4-1 Europa League win over Wolfsburg on Thursday while Celtic and Tottenham were held to draws in tricky away assignments.
Celtic face a tough trip to Salzburg on Thursday, the day of Scotland's independence referendum, while Everton host Wolfsburg and Tottenham go to Partizan Belgrade as the epic quest for the Europa League reaches the 48-team group phase.
Barcelona midfielder Xavi Hernandez insisted he hasn't been frustrated by his lack of opportunities under new boss Luis Enrique after starting for the first time this season in a much-changed side in a 1-0 victory over APOEL Nicosia.
Jerome Boateng's late goal and a second-half equaliser from Klaas-Jan Huntelaar on Wednesday completed a good week for German clubs against their counterparts from England in the opening round of Champions League group games.
Barcelona begin their Champions League campaign at home to Cypriot champions APOEL Nicosia on Wednesday in fine form having romped to the top of La Liga with three consecutive wins to give Luis Enrique a dream start to his reign.
Steven Gerrard was Liverpool's hero with a stoppage-time penalty as the Reds marked their return to the Champions League with a win on Tuesday, while Arsenal endured a torrid evening against Borussia Dortmund.
Liverpool's return to Champions League action for the first time in five years and Real Madrid's shaky start to the season dominate the start of the battle for European football's elite club competition on Tuesday.
Bayern Munich playmaker Franck Ribery scored in his first game this season as the champions moved joint top of the Bundesliga on Saturday, while Shinji Kagawa also enjoyed a goalscoring return as Borussia Dortmund saw off Freiburg.