Mertesacker wins 100thcap, Ghana's Appiah rings changes
Germany's defender Per Mertesacker gives a press conference in Santo Andre on June 19, 2014 as part of the FIFA 2014 World Cup in Brazil - by Patrik Stollarz
Vice-captain Bastian Schweinsteiger has to again be content with a place on the bench while Thomas Mueller, who scored a hat-trick against Portugal, starts ahead of veteran striker Miroslav Klose.
Mats Hummels won his race to be fit after suffering a thigh injury in Salvador on Monday and partners Mertesacker in central defence.
Ghana coach Kwesi Appiah made four changes to the side which lost their opening game against the United States.
Goalkeeper Abual-Fatawu Duada started for Adam Kwarasey, while Kevin-Prince Boateng comes into the side.
The Berlin-born Schalke 04 star will face his half-brother Jerome Boateng, who is at right-back for Germany.
Manuel Neuer; Jerome Boateng, Mats Hummels, Per Mertesacker, Benedikt Hoewedes; Philipp Lahm (capt), Sami Khedira; Mesut Ozil, Toni Kroos, Mario Goetze; Thomas Mueller
Coach Joachim Loew (GER)
Abual-Fatawu Dauda, Christian Atsu, Kevin-Prince Boateng, Andre Ayew, Sulley Muntari, Mohammed Rabiu, Jonathan Mensah, John Boye, Harrison Afful, Asamoah Gyan (capt), Kwadwo Asamoah
Coach: Kwesi Appiah (GHA)
Referee: Sandro Ricci (BRA)