Mkhitaryan, Aubameyang on target again for Dortmund
Borussia Dortmund's Pierre-Emerick Aubameyang (r) celebrates his goal with Henrikh Mkhitaryan during their match against Stuttgarter Kickers on August 16, 2014 in Stuttgart - by Sebastian Kahnert
Mkhitaryan opened the scoring in the 30th minute of the first-round tie aga inst their third-tier hosts, with Aubameyang grabbing a brace through goals in the 55th and 78th minutes before new signing Adrian Ramos added the fourth, one minute from time.
Dortmund were also boosted by the return of Marco Reus, 10 weeks after the ankle injury which ruled him out of the World Cup, and Neven Subotic who played his first game in nine months after suffering right knee ligament damage.
Bayer Leverkusen reached the second round on Friday with Stefan Kiessling scoring five times in a 6-0 rout of fifth division Alemania Waldalgesheim.
There were also wins for Borussia Moenchengladbach, Hertha Berlin, Hanover and Cologne, but VfB Stuttgart and Mainz both suffered early exits.
Bayern Munich, without Franck Ribery, Bastian Schweinsteiger and Javi Martinez, begin their defence of the trophy on Sunday with a trip to third division Preussen Münster.