Ronaldo starts on verge of European record
Real Madrid's Portuguese forward Cristiano Ronaldo jokes during a training session at the Valdebebas training ground in Madrid on April 1, 2014 - by Pierre-Philippe Marcou
The Portuguese already has 13 goals from just seven appearances in the competition this campaign and is joined in attack at the Santiago Bernabeu by Karim Benzema and Gareth Bale.
Marcelo and Angel di Maria miss out for Madrid due to injury and illness respectively, so Fabio Coentrao and Isco are handed rare starts.
Dortmund are without six first team regulars due to injury and suspension in all, including top scorer Robert Lewandowski.
The Polish striker's absence means Gabonese international Pierre-Emerick Aubameyang is expected to start in an unusual position as the central striker.
Real Madrid (4-3-3)
Iker Casillas (capt); Dani Carvajal, Sergio Ramos, Pepe, Fabio Coentrao; Xabi Alonso, Isco, Luka Modric; Gareth Bale, Karim Benzema, Cristiano Ronaldo
Coach: Carlo Ancelotti (ITA)
Borussia Dortmund (4-2-3-1)
Roman Weidenfeller; Lukasz Piszczek, Sokratis, Mats Hummels, Erik Durm; Sebastian Kehl (capt), Nuri Sahin; Marco Reus, Henrikh Mkhitaryan, Kevin Grosskreutz; Pierre-Emerick Aubameyang
Coach: Jurgen Klopp (GER)
Referee: Mark Clattenburg (ENG)