Teams named for 2014 NFL games in London
Phillip Tanner of the Dallas Cowboys takes the handoff from quarterback Tony Romo on October 20, 2013 at Lincoln Financial Field in Philadelphia
The league had announced earlier this month that the Jacksonville Jaguars, Atlanta Falcons and Oakland Raiders had been designated the host teams for 2014 games at Wembley.
The Jaguars will face the Dallas Cowboys, the Falcons will take on the Detroit Lions and the Raiders will play the Miami Dolphins.
Dates have yet to be announced.
"Our fans in the UK continue to demonstrate their passion for more football," NFL commissioner Roger Goodell said in a statement.
"Next year for the first time we will play three regular-season games in London. We have scheduled three attractive games with four teams playing in their first International Series game. The growing enthusiasm for the NFL internationally is exciting and we look forward to continuing to respond to this interest in our game."
Sunday's clash between the Jaguars and 49ers at Wembley will be the league's second game in London this season. On September 29, the Minnesota Vikings beat the Pittsburgh Steelers 34-27 before 83,518 spectators.
The Jaguars have committed to playing one "home" game in London for four straight seasons, through 2016.
They have a London link through owner Shahid Khan, who also owns English Premier League club Fulham.